What does “Entourage effect” mean?
The hypothesis that the compounds in cannabis work better together than any of them does in isolation.
Entourage effect in plain English
The hypothesis that the compounds in cannabis work better together than any of them does in isolation.
The weak form of the claim — that these compounds interact — is well supported, particularly the finding that CBD moderates some unwanted effects of THC.
The strong form — that whole-plant preparations produce better clinical outcomes than isolated cannabinoids in patients — has not been demonstrated in controlled trials. The distinction matters, because the term is often used to justify product recommendations it cannot support.
Frequently asked questions
What does entourage effect mean?
The hypothesis that the compounds in cannabis work better together than any of them does in isolation.
Sources and further reading
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