What does “Tolerance” mean?
A reduced response to the same amount of a drug after repeated exposure.
Tolerance in plain English
A reduced response to the same amount of a drug after repeated exposure.
Repeated THC exposure reduces the availability of CB1 receptors, so the same amount produces less effect. Tolerance to intoxicating and sedating effects tends to develop faster than tolerance to therapeutic effects.
A pattern of needing steadily more for the same result is a signal to reassess the treatment rather than to keep increasing.
Frequently asked questions
What does tolerance mean?
A reduced response to the same amount of a drug after repeated exposure.
Sources and further reading
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